If you experience crash reports that include "Out of Memory", please try closing any non-essential programs that may be running in the background before starting Pyre.

If that doesn't help, you can also try setting this launch option: /BinkStreamCacheSize=0 

To set Launch Options:

  1. Right-click on Pyre under the Library in Steam and select Properties.
  2. Under the General tab click the Set launch options... button.
  3. Enter /BinkStreamCacheSize=0 and click OK.
  4. Close the game's Properties window and launch the game.